Dresden 2017 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 60: Physics of Parasites - Joint Focus Session (BP/DY) organized by Holger Stark
BP 60.6: Vortrag
Freitag, 24. März 2017, 12:00–12:15, SCH A251
Pre-clinical testing of a novel malaria diagnostic device — •Petra Molnar1, Agnes Orban1, Adam Butykai1, Maria Pukancsik1, Istvan Kezsmarki1, Tivadar Zelles2, Istvan Kucsera3, Jetsumon Prachumsri4, and Stephan Karl5 — 1Dept of Physics, Budapest Uni. of Technology and Economics and MTA-BME Lendület Magneto-optical Spectroscopy Research Group, 1111 Budapest, HU — 2Dept of Oral Biology, Semmelweis Uni.,1089 Budapest, HU — 3National Center for Epidemiology, 1097 Budapest, HU — 4Mahidol Vivax Research Center (MVRC) of Mahidol Uni., Bangkok, TH — 5Infection and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, AU
We have developed a compact and inexpensive rotating-crystal magneto-optical diagnostic (RMOD) device based on the detection of hemozoin crystals, a metabolic byproduct of all Plasmodium species. The first step of the in-field validation had been carried out in Thailand. To assess the diagnostic performance of the RMOD technique, 50 field-collected frozen human blood samples were measured at the MVRC. The RMOD method was also tested in collaboration with Dr. Stephan Karl, using field samples (n≈800) previously collected from symptomatic children prior to treatment and following combination therapies at Modilon Hospital in Papua New Guinea. These samples, well characterized by light microscopy and quantitative PCR, have offered an ideal opportunity to i) assess the diagnostic capability of the RMOD method and ii) study the hemozoin clearance kinetics in patient samples.