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Q: Quantenoptik

Q 38: Laser in Medicine

Q 38.5: Vortrag

Freitag, 6. April 2001, 18:30–18:45, H 2013

Trace gas analysis of human breath using infrared cavity leak-out spectroscopy — •Daniel Kleine1, Hannes Dahnke1, Wolfgang Urban2, Peter Hering1, and Manfred Mürtz11Institut für Lasermedizin, Universität Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany — 2Institut für Angewandte Physik, Universität Bonn, Wegelerstr. 8, 53113 Bonn, Germany



After the successful evaluation of Cavity Leak-Out Spectroscopy (CALOS) for the analysis of atmospheric trace gases [1,2] we now introduce medical applications. The measurement of trace gases in human breath opens the possibility of early diagnosis of illnesses and human cell damage. By detection of the ethane (C2H6) concentration in human breath it is possible to monitor the oxidative stress status of the human body. CALOS is closely related to cavity ring-down spectroscopy and uses narrowband cw lasers in the mid- infrared spectral range. Our trace gas measurements are carried out with a CO overtone sideband laser in the 3 µm range. The noise equivalent absorption coefficient of this frequency tuneable spectrometer is 1.7 × 10−9/cm. This high sensitivity permits real-time analysis of endogeneous trace gases in human breath on the sub-ppb level without preconcentration of the gas samples.

[1] D. Kleine, H. Dahnke, W. Urban, P. Hering, M. Mürtz; Opt. Lett. 25, 1606 (2000); [2] H. Dahnke, D. Kleine, W. Urban, P. Hering, M. Mürtz; Appl. Phys. B 71, 873 (2001)

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