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AKB: Biologische Physik

AKB 200: Poster Session II

AKB 200.3: Poster

Tuesday, March 8, 2005, 17:00–19:00, Poster TU C

Small angle scattering study of intermolecular interactions in protein solutions — •Marc Niebuhr und Michel H.J. Koch — European Molecular Biology Laboratory, Hamburg Outstation, EMBL c/o DESY, Notkestrasse 85, D-22603 Hamburg, Germany

The results a study of intermolecular interactions in protein solutions measured with small angle X-ray scattering are presented. According to the DLVO theory the main interactions between spherical particles are the hard-sphere interactions, a short range attraction, due to surface-surface forces, and a long range repulsion caused by the fact that the particles are charged. The most interesting finding is that structure factors of salt concentration series and their change upon addition of urea and TMAO are better described if the strength of the attractive potential decreases with increasing salt concentration. Previous work in the literature had relied on a constant attractive potential within a given series of measurements.