Berlin 2005 – wissenschaftliches Programm
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AKB: Biologische Physik
AKB 30: Biomaterials
AKB 30.2: Vortrag
Freitag, 4. März 2005, 17:45–18:00, TU H2013
The Influence of the Thermal Treatment of Hydroxylapatite Scaffolds on the Physical Properties and the Bone Cell Ingrowth Behaviour — •Alexander Woesz1, Monika Rumpler1, Inderchand Manjubala1, Christine Pilz1, Franz Varga2, Nadja Fratz-Zelman2, Paul Roschger2, Klaus Klaushofer2, Juergen Stampfl3, and Peter Fratzl1 — 1Max Planck Institute of Colloids and Interfaces, Dept. of Biomaterials, Potsdam , Germany — 2Ludwig Boltzmann Institute of Osteology, 4th Medical Department, Vienna, Austria — 3Institute of Materials Science and Technology, University of Technology, Vienna, Austria
The usage of rapid prototyping (RP) methods and ceramic gelcasting enables the production of 3D scaffolds as future bone replacement materials with almost arbitrary architecture from bioceramics like hydroxylapatite. A suspension of synthetic hydroxylapatite powder in water was cast into a mould produced by RP-methods. After demoulding the ceramic particles were sintered. Sintering temperature and atmosphere affected the physical properties like phase composition and surface roughness as well as the cell ingrowth behaviour, which was assessed in cell culture experiments using a pre-osteoblastic cell line. With increase in sintering temperature decomposition of the synthetic hydroxylapatite into tricalciumphosphate increased, the sintering atmosphere seemed to influence the surface roughness, but had no impact on the phase composition. Cell ingrowth was observed to be highest at a sintering temperature of 1300∘C in nitrogen atmosphere followed by a post-treatment at 1200∘C in air.