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Berlin 2005 – scientific programme

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CPP: Chemische Physik und Polymerphysik

CPP 30: POSTER: Chemical physics

CPP 30.41: Poster

Tuesday, March 8, 2005, 16:30–18:30, Poster TU D

Mechanisms of Protein Resistance in Oligo (Ethylene Glycol) Self-Assembled Monolayers: A Neutron Reflecitvity and FTIR Study — •M. Skoda1, F. Schreiber1, J. Willis1, R. Jacobs1, R. Dahint2, M. Grunze2 und M. Wolff31Phys. and Theor. Chemistry Laboratory, Univ. of Oxford, Oxford OX1 3QZ — 2Angew. Phys. Chemie, Univ. Heidelberg, 69120 Heidelberg — 3ILL, 38042 Grenoble-France

For the efficient development of custom designed oligo (ethylene glycol) (OEG) protein resistant coatings a thorough understanding of the underlying mechanisms leading to the repulsion of proteins in these self-assembled monolayers (SAMs) is necessary[1,2]. In this context [3] protein resistent OEG SAMs and their interactions with proteins in aqueous solutions have been studied in situ using neutron reflectivity (NR). Complementary data were taken using IR and optical spectroscopy. Sample parameters (temperature, ionic strength, pH and protein charge) have been varied to determine the values for the onset of the breakdown of the non-fouling properties. The NR data analysis was focused on the formation of a protein depleted zone in the proximity of the SAM/water interface. The shape of the concentration profile of the proteins was extracted from the data. Finally,a comprehensive discussion of the various control parameters influencing the protein resistance and the structure at the interface is attempted.

[1] Prime, K. L. et al., G. M.,Science,1991,252,1164;

[2] Schreiber, F., J. Phys.: Condens. Matter,2004,16,R881;

[3] Zheng, J. et al.,Langmuir,2004,20,893

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