Berlin 2005 – wissenschaftliches Programm

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ST: Strahlen- und Medizinphysik

ST 7: Strahlenphysik: Strahlenbiophysik I

ST 7.3: Fachvortrag

Mittwoch, 9. März 2005, 11:00–11:15, TU HL1

The GSI heavy ion microbeam: a new tool for the investigation of cellular response to high LET radiations. — •Barberet P., Fischer B.E., Heiss M., Du G., and Taucher-Scholz G. — GSI Plankstr.1 64291 Darmstadt

Since the mid 90s, an increasing number of charged particle microbeams have been designed to deliver an exact number of ions on individual cells cultured in vitro with a lateral resolution of a few microns. This irradiation technique is of particular interest for the investigation of the cellular response to low doses of radiations. Since 1987, a single ion hit technique is in operation on the GSI heavy ion microbeam. During the last years, this facility has been upgraded for the irradiation of individual living cells in culture. This set-up presents two main peculiarities compared to the microbeams used up to now for cell irradiation. First, the beam micrometric size is obtained by focusing and not by a simple collimation. This allows to obtain a smaller beam spot, a better defined LET, and a high irradiation throughput. Then, the GSI microbeam is able to focus ions from carbon to uranium with energies between 1.4 MeV/u to 11.4 MeV/u. The range of accessible LET is thus considerably extended compared to light ions microbeam in operation today. The design of the GSI microbeam will be described, including the beam control, the online cell localization, the cell dish designed specifically for microbeam irradiation and the cell irradiation procedures. The different tests performed to check the reliability of the system will also be presented. At last, a brief overview of the possible applications of such a microbeam in radiation biology studies will be exposed.