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Dresden 2006 – scientific programme

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CPP: Chemische Physik und Polymerphysik

CPP 25: POSTER Electronic Structure and Spectroscopy

CPP 25.6: Poster

Thursday, March 30, 2006, 17:00–19:00, P2

CIDNP and 19F-1H Spin Polarization Transfer in 3-Fluorotyrosine — •Sergey Korchak1, Vitor Nascimento de Carvalho Pinto1, Konstantin Ivanov2, and Hans-Martin Vieth11Department of Physics, Free University of Berlin, Arnimallee 14, D-14195 Berlin, Germany — 2International Tomography Center of SB RAS, 630090, Institutskaya 3a, Novosibirsk, Russia

The transfer of dynamic spin polarization between different nuclei in biological molecules can be used for labeling specific nuclear positions and applied to NMR spectroscopy in biology and medicine or for sensitivity enhancement in magnetic resonance imaging. Here, we report on strong Chemically Induced Dynamic Nuclear Polarization (CIDNP) created in reversible photoreactions between biological molecules and triplet exited dyes involving transient radical pairs. In particular, the 19F-1H polarization transfer in CIDNP experiments with 3-fluoro-DL-tyrosine is examined by means of 19F-CIDNP and 1H-CIDNP. For the first time, the magnetic field dependence of 19F-CIDNP at 0-7 T is obtained. The mechanism of polarization transfer is revealed and optimum conditions for getting high spin polarization transfer are discussed. By comparing the experimental results with model calculations the g-factor of the 3-fluorotyrosine radical is obtained. The fluorinated amino acids incorporated in proteins may be used for the investigation of protein folding with the advantage that fluorine exhibits a higher CIDNP effect than proton and that the background 1H polarization is absent.

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