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BP: Fachverband Biologische Physik
BP 17: Poster II
BP 17.39: Poster
Wednesday, March 25, 2009, 17:15–19:45, P3
Spatial desynchronization of glycolytic waves as revealed by Karhunen-Loève analysis — Satenik Bagyan1, Ronny Straube2, •Marcus J.B. Hauser1, and Thomas Mair1 — 1Otto-von-Guericke University, Institute of Experimental Physics, Biophysics Group, Universitätsplatz 2, 39106 Magdeburg, Germany — 2Max-Planck-Institute for Dynamics of Complex Technical Systems, Department of Systems
Glycolysis is the central pathways of the energy metabolism in almost all living beings. The dynamics of glycolytic waves in a yeast extract have been investigated in an open spatial reactor. A transition from inwardly moving target patterns to outwardly moving spiral or circular shaped waves has been observed during the course of the experiments. These two phases are separated by a transition phase of more complex spatio-temporal dynamics. The dynamics of the patterns observed at these three intervals was analysed at different spatial scales by means of a Karhunen--Loeve (KL) decomposition. During the initial phase of the experiment the patterns are sufficiently described by the 2 dominant spatially invariant KL modes independently of the spatial scale. However, during the last stage of the experiment this spatial invariance is lost and at least 6 KL modes are required to account for the observed patterns at spatial scales larger than 3 mm while for smaller scales 2 KL modes are still sufficient. This indicates that in the course of the experiment the local glycolytic oscillators become desynchronized at spatial scales larger than 3 mm. We discuss possible reasons for the desynchronization of the glycolytic waves.