Dresden 2009 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 18: Regulation and Signaling

BP 18.1: Hauptvortrag

Donnerstag, 26. März 2009, 09:30–10:00, HÜL 186

Systems biology of yeast cell signaling and response to stress — •Edda Klipp — Humboldt-Universität zu Berlin, Dept. of Biology, Theoretical Biophysics

Life is change. In order to study and understand life, it is necessary, but not sufficient to study genes, proteins or metabolites, and networks thereof in static conditions. Instead, we must handle the dynamic action. Stress and external perturbations are means to study the wiring of biochemical networks or signal transduction pathways and to understand the underlying regulatory principles.

Over the last years, we have studied various signal transduction and regulatory pathways in a model organism, the yeast Saccharomyces cerevisiae, and investigated the response of cells to external perturbations on various levels. To this end, we have established mathematical models, reflecting physical properties such as reaction kinetics, thermodynamic constraints as well as fluxes and forces. They are mainly in form of ordinary differential equation systems. Their structure and parameters are based on publicly available information and new dynamic data measured by our experimental collaborators. Here, I will focus on results with respect to interaction of different signaling and regulatory pathways. Specifically, new aspects in cell cycle regulation and the interaction of stress-activated signaling pathways with cell cycle progression will be discussed. The results indicate that yeast cells have developed different mechanisms for coping with external stress during different periods of their life time.