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BP: Fachverband Biologische Physik

BP 2: Protein Structure \& Dynamics

BP 2.2: Talk

Monday, March 14, 2011, 10:45–11:00, ZEU 260

Mechanism of signal transduction of the LOV2-Jα-photosensor from Avena sativa — •Emanuel K. Peter, Bernhard Dick, and Stephan A. Baeurle — Fakultaet für Chemie und Pharmazie, Universitaet Regensburg, 93040 Regensburg, Deutschland

Fusion proteins containing light-activable protein domains possess great potential as molecular switches in cell signaling and for controlling enzymatic reactivity. This has recently been impressively demonstrated in living cell experiments through connecting the blue light-activable LOV2-Jα-protein domain from phototropin1 of Avena sativa (AsLOV2-Jα) with the Rac1-GTPase, responsible for regulating the morphology and motility of metazoan cells. However, a target-oriented development of fusion proteins in conjunction with the AsLOV2-Jα-photosensor is still very challenging, because a detailed understanding of its signal transduction pathway on a molecular level is still lacking. In this presentation we elucidate the mechanism of signal transduction of this photosensor on a molecular level, which opens new perspectives for the creation of light-activable molecular switches and enzymes [1].

[1] E. Peter, B. Dick and S. A. Baeurle, Nature Communications 1 : 122 (2010); doi: 10.1038/ncomms1121 (2010)