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BP: Fachverband Biologische Physik

BP 28: Statistical Physics in Biological Systems IV (joint DY, BP)

BP 28.6: Talk

Thursday, March 17, 2011, 15:30–15:45, ZEU 260

Dynamics of mutants in a stochastic compartment approach of hematopoiesis — •Benjamin Werner and Arne Traulsen — Research Group for Evolutionary Theory, Max Planck Institute for Evolutionary Biology, 24306 Plön

Cancer is typically caused by at most a handful of mutations that increase the reproductive fitness of a single cell. The probability of such a mutation, the dynamics of the resulting clone of cancer cells, and thus the effect to an organism is under intense investigation. First we present an established stochastic multicompartment model of hematopoiesis [1,2] (CML) as well as other blood disorders [3,4] can be embedded and analyzed in this framework. We show that there is a closed deterministic solution to the dynamics of mutants in this model that fits the averages of the stochastic process. This solution enables us to connect different model parameters directly to observed cell dynamics and thus gives in principle yet unknown information about disease progression and the impact of drug treatment.

Ref.:

[1] D. Dingli, A. Traulsen and J. M. Pacheco,

  PLoS ONE 2, e345 (2007).

[2] D. Dingli, A. Traulsen, T. Lenaerts and J. M. Pacheco,

  Genes & Cancer 1(4) 309-315 (2010).

[3] D. Dingli, J. M. Pacheco and A. Traulsen,

  Phys. Rev. E 77, 021915 (2008).

[4] A. Traulsen, J. M. Pacheco, L. Luzzatto and D. Dingli,

  BioEssays Vol.32 Issue 11 (2010).