Berlin 2012 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 2: Advanced Diagnostic Imaging II
ST 2.2: Vortrag
Montag, 26. März 2012, 15:20–15:40, HFT-FT 101
Preliminary results from a first preclinical x-ray phase-contrast CT scanner — •Astrid Velroyen1, Arne Tapfer1, Martin Bech1, Bart Pauwels2, Peter Bruyndonckx2, Xuan Liu2, Alexander Sasov2, and Franz Pfeiffer1 — 1Department of Physics and Institute of Medical Engineering (IMETUM), Technische Universität München, Germany — 2Skyscan, Kontich, Belgium
Conventional absorption-based x-ray imaging of biomedical samples provides only weak soft-tissue contrast. This limitation can be addressed by phase-contrast imaging, which exploits the phase shift that x-rays undergo when passing through an object. The phase shift, apparent in a minimal angular refraction of the x-ray, can be measured by grating-based interferometric methods at laboratory x-ray sources. Using this technique, improved soft-tissue contrast can be achieved and great potential for medical imaging is anticipated. As a first step towards clinical implementation, we have developed a grating-based compact preclinical phase-contrast CT scanner with rotating gantry, from which we present the first results of soft tissue samples. In particular, the effect of the rotational movement of the gantry on the interferometric image acquisition is characterized and the consequent challenges for image preprocessing and image formation are presented. First scans of biological samples clearly show the improved soft-tissue contrast and hence prove the feasibility of phase-contrast x-ray tomography with a compact rotating gantry system.