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BP: Fachverband Biologische Physik
BP 19: Focus Session: Dynamical Patterns in Neural Systems: From Brain Function to Dysfunction (joint DY/BP)
BP 19.4: Talk
Tuesday, April 1, 2014, 11:00–11:15, HÜL 186
Fast reconfiguration of high-frequency human brain networks in response to surprising changes in auditory input — •Sandra Chapman1,2,3, Ruth Nicol4, Petra Vertes5, Pradeep Nathan5,6, Marie Smith7, Yury Shtyrov8, and Edward Bullmore5,6 — 1CFSA, Physics, Univ. of Warwick, UK — 2MPIPKS, Dresden, Germany — 3Mathematics and Statistics, UIT, Norway — 4University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK — 5Behavioral and Clinical Neuroscience Institute, Dept. of Psychiatry, Univ. of Cambridge, UK — 6GSK Clinical Unit, Addenbrooke's Hospital, Cambridge, UK — 7Dept. of Psychological Sciences, Birkbeck, Univ. of London, UK — 8MRC Cognition and Brain Sciences Unit, Cambridge, UK
We measured rapid changes in functional brain network organization in response to brief, discrete, changes in auditori stimulii. We estimated network topology and distance parameters in the immediate response, < 1 s, following auditory presentation of standard, repeated tones interspersed with occasional 'surprising' tones, using MEG to measure synchronization of high frequency (gamma band 33-64 Hz) oscillations in healthy volunteers. We found that global small-world parameters of the networks were unchanged between the standard and surprising tones. However, auditory surprises were associated with local changes in clustering of connections between temporal and frontal cortical areas, and with increased interlobar, long-distance synchronization. This work maps the dynamic network response that corresponds to the well known evoked response to this mismatch-negativity paradigm.