Wuppertal 2015 – wissenschaftliches Programm

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ST: Fachverband Strahlen- und Medizinphysik

ST 4: Radiation Therapy & Dosimetry I

ST 4.9: Vortrag

Dienstag, 10. März 2015, 18:45–19:00, BZ.08.02 (HS 3)

Modeling radiation effects of ultrasoft X-rays based on their microscopic dose deposition pattern — •Tamara Buch1,2, Emanuele Scifoni1, Marco Durante1,2, Michael Scholz1, and Thomas Friedrich11GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany — 2Institut für Festkörperphysik, TU Darmstadt, Germany

Understanding and characterization of different radiation types and their biological effectiveness are essential for radiation protection as well as for medical applications such as radiation therapy. Modeling approaches aim to predict radiation effects and in turn give insight into radiation damage processes. It is known that irradiation with ultrasoft X-rays (USX) shows a higher effectiveness than high-energy photons. This is attributed, similar as for high LET radiation, to a rather inhomogeneous dose deposition. A mechanistic modeling approach is given by the Local Effect Model (LEM), developed at GSI, Darmstadt. One of its basic concepts is that the biological effectiveness mainly depends on the accumulation of double-strand breaks (DSB) within DNA substructures called chromatin loops. A higher effectiveness can thereby be sufficiently explained by an increasing yield of DSB and their spatial arrangement. As a preliminary step, we attempt to predict this increase of DSB on the basis of an amorphous track structure, exploiting the inhomogeneous dose deposition caused by the considerably smaller range of secondary electrons and the higher significance of attenuation of the photons itself. Since no insight into dose responses of USX is required this work presents a direct extension of LEM for USX.

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