Regensburg 2016 – scientific programme

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BP: Fachverband Biologische Physik

BP 16: Posters - Computational Biophysics

BP 16.9: Poster

Monday, March 7, 2016, 17:30–19:30, Poster C

Monte-Carlo-Simulations of Cellular Adhesion — •Filip Savić, Andreas Janshoff, and Burkhard Geil — Georg-August-Universität Göttingen, Institut für Physikalische Chemie, Tammannstraße 6, 37077 Göttingen, Germany

The adhesion of cells to the extracellular matrix is an important process in biology. To understand the physical processes involved in the on state of cellular adhesion, especially the lateral organization of adhesion molecules into clusters, we perform Monte-Carlo-Simulations based on a harmonic multi-spring model involving lipid membranes and their physical properties. Local deformation of the membrane in the vicinity of adhesion clusters facilitates cluster growth while a repulsive interaction between clusters arises due to an interplay of membrane bending rigidity and non-specific repulsion. Balance of this interaction governs cluster size and stability in our simulations.