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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 42: Focus: Multiscale Simulations for Soft Matter: The Challenge of Dynamics (joint session CPP/DY, organized by CPP)

CPP 42.8: Invited Talk

Wednesday, March 9, 2016, 17:15–17:45, H51

Principle of Maximum Caliber and its application in biology — •Kingshuk Ghosh — University of Denver

We will describe the principle of Maximum Caliber (MaxCal), a variational approach to model dynamical fluctuations. MaxCal is similar to the Maximum Entropy principle but applied in the trajectory space, natural language in describing several biological systems ranging from macromolecular dynamics to networks. We will briefly describe the general formalism and show the equivalence between MaxCal and Markov processes. Next we will present application of MaxCal to model stochastic dynamics in biological systems, in particular genetic networks. These applications will highlight the role of MaxCal in describing complex systems with cooperativity, non-linearty and feedback in a coarse-grained manner and yet provide us with quantitative tools to analyze data and gain valuable insights.