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SYLM: Symposium Laser in der Medizin

SYLM 1: Laser in der Medizin I

SYLM 1.1: Invited Talk

Tuesday, March 14, 2017, 14:00–14:30, GW1 HS

Mechanisms of plasma-mediated surgery of cells and tissues — •Alfred Vogel, Xiao-Xuan Liang, Sebastian Freidank, and Norbert Linz — Institute of Biomedical Optics, University of Luebeck, Germany

Laser-induced plasma generation and plasmonics are used for intraocular, refractive and cataract surgery as well as for gene transfection into cells and for targeted effects via antibody-conjugated nanoparticles. We investigated the sequence of events from plasma formation through acoustic emission, bubble formation and subsequent bubbles oscillations both experimentally and theoretically for bubble sizes in the micrometer and nanometer range. Photographs of luminescent plasmas and transmission measurements allowed for determining the plasma energy density, and interfereometric measurements enabled us to record the bubble dynamics in single-shot measurements with nanometer accuracy and 160 ps time resolution. These experimental data provide the input for a model that tracks energy flow and partitioning, as well as pressure evolution and shock wave emission from plasma formation throughout the entire bubble life time. Changes associated with decreasing bubble size will be demonstrated, and consequences for biomedical applications discussed.