Dresden 2017 – wissenschaftliches Programm

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DY: Fachverband Dynamik und Statistische Physik

DY 54: Posters - Pattern Formation, Reaction Diffusion, Chimera

DY 54.7: Poster

Donnerstag, 23. März 2017, 17:00–19:30, P1A

Modeling and simulation of vascular endothelial calcium waves induced by blood shear stress — •Hengdi Zhang and Chaouqi Misbah — Liphy, Laboratoire Interdisciplinaire de Physique, 140 Rue de la Physique, 38402 Saint-Martin-d Heres, France

Vascular endothelial cells form an inner monolayer in human blood vessel. As they are directly contacting with blood flow, a lot of blood vessel functions are modulated or initiated by them, such as vasodilation / vasoconstriction in blood pressure control and angiogenesis in wound healing. These functions require endothelial cells to be capable of sensing its micro environment changes and signaling to surrounding tissues. One of the most important micro environments is the blood flow induced shear stress on the endothelial surface. Endothelial cells respond to the shear stress change in multiple time scales. But for the very first tens of seconds during and after the shear stress change, a transient increase in cytosolic free calcium ion concentration will take place. This calcium signal involves and triggers signaling cascades in many endothelial functions. To get a further understating to this signal, we analyzed possible candidates of endothelial mechanical sensors from relevant literatures, and integrated them into a convection-diffusion-reaction model coupled with shear / shear-rate dependent complex boundary conditions. A Lattice-Boltzmann method is employed to solve the system numerically. Responses to different flow condition and roles of mechanical sensor candidates are investigated in this research.