Dresden 2017 – scientific programme

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MM: Fachverband Metall- und Materialphysik

MM 11: Biomaterials

MM 11.1: Talk

Monday, March 20, 2017, 11:45–12:00, IFW D

Macromolecular HPMA-based drug delivery system - behavior in protein environment — •Xiaohan Zhang¹, Bart-Jan Niebuur¹, Petr Chytil², Tomas Etrych², Sergey K. Filippov², Alexey Kikhney³, Florian Wieland³, Dmitri I. Svergun³, and Christine M. Papadakis¹ — ¹Technische Universität München, Physik-Department, Fachgebiet Physik weicher Materie, Garching, Germany — ²Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic — ³European Molecular Biology Laboratory, DESY, Hamburg, Germany

Copolymers based on N-(2-hydroxypropyl)methacrylamide (HPMA) having cholesterol side groups self-assemble into ellipsoidal nanoparticles (NPs) in aqueous solutions [1,2]. The core and the shell are formed by cholesterol and by HPMA, respectively. They have been proposed as drug carriers. However, little is known on their behavior in human blood environment.

We use synchrotron small-angle X-ray scattering (SAXS) to investigate HPMA copolymers in an aqueous solution of human serum albumin(HSA), which is very abundant in human blood, to investigate the influence of HSA on the NPs' structure. The length of the NPs is reduced even if very small amounts of HSA are present. We speculate that HSA binds to cholesterol groups and removes them from the NPs.

[1] S. K. Filippov, et al., Biomacromolecules, 2012, 13, 2594

[2] S. K. Filippov, et al., Biomacromolecules, 2013, 14, 4061