Berlin 2018 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 16: Membranes and Vesicles I (joint session BP/CPP)

BP 16.8: Vortrag

Mittwoch, 14. März 2018, 11:45–12:00, H 1028

Formation of Coatless Membrane Vesicles — •Susanne Liese1, Rossana Rojas1, Eva Wenzel2, Camilla Raiborg2, Harald Stenmark2, and Andreas Carlson11University of Oslo, Department of Mathematics — 2Oslo University Hospital, Institute for Cancer Research

The formation of membrane vesicles is an important part of various processes in cell biology. Among others, cells use vesicle formation as an uptake mechanism for controlling their activity and to communicate with other cells through the cargo material that is encapsulated in the membrane vesicle. It all starts with a small initial deformation of the membrane, which subsequently grows and leads to the formation of a vesicle. This dynamic process is induced by membrane associated proteins, which generate forces within the membrane. Membrane compartments inside the cell, such as the endosome, form coatless vesicles but the force generating membrane proteins are not becoming a part of the vesicle. To understand this process, we develop an elastic membrane model to study the biophysical origin of coatless vesicle formation. Our results highlight how elastic membrane parameters and transmembrane proteins determine the shape of the deformed membrane and the equilibrium size distribution of vesicles.

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