Berlin 2018 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 7: Focus Session: Statistical Physics-Based Methods in Molecular Evolution - organized by Alexander Schug and Martin Weigt (joint session BP/DY)

BP 7.6: Vortrag

Montag, 12. März 2018, 16:30–16:45, H 2013

Interprotein coevolution: bridging scales from residues to genomesGiancarlo Croce1, Thomas Gueudre2, Hendrik Szurmant3, Matteo Figliuzzi1, and •Martin Weigt11Université Pierre & Marie Curie, Sorbonne Université, Paris, France — 2Human Genetics Foundation, Turin, Italy — 3Western University of Health Sciences, Los Angeles, USA

Interacting proteins coevolve at multiple but interconnected scales, from the residue-residue over the protein-protein up to the family-family level. The recent accumulation of enormous amounts of sequence data allows for the development of novel, data-driven computational approaches. Notably, these approaches can bridge scales within a single statistical framework [1,2], which is built upon idea from the inverse statistical physics [3,4]. While being currently applied mostly to isolated problems on single scales, their immense potential for an evolutionary informed, structural systems biology is steadily emerging.

[1] H. Szurmant and M. Weigt, Current Opinion in Structural Biology 50, 26-32 (2017).

[2] G. Croce, T. Gueudre, MV Ruiz Cuevas, H. Szurmant, M. Figliuzzi, M. Weigt, submitted (2017).

[3] S. Cocco, C. Feinauer, M. Figliuzzi, R. Monasson, M. Weigt, Rep. Prog. Phys. (2017), https://doi.org/10.1088/1361-6633/aa9965.

[4] H. Chau Nguyen, Riccardo Zecchina, Johannes Berg, Advances in Physics, 66 (3), 197-261 (2017)

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