Berlin 2018 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 9: Postersession I

BP 9.38: Poster

Montag, 12. März 2018, 17:30–19:30, Poster A

Clocks and timers in genetic networks. — •Jose Negrete JR1,2, Ivan M. Lengyel1,3, Laurel A Rohde2, Andrew C. Oates2, and Frank Jülicher11Max Planck Institute for the Physics of Complex Systems, Dresden, Germany — 2École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland — 3Instituto de Investigación en Biomedicina de Buenos Aires CONICET of, Argentina

Genetic oscillations are noisy and in many cases, as in embryo development, short lived. We present a model of a noisy transcription factor that controls the timing and amplitude of an stochastic genetic oscillator. The transcription factor determines how long the oscillator is on and it is denominated as a timer, while the genetic oscillator is denominated as a clock due to its repetitive nature. The model is given by a single delay differential equation, and we show analytically the set of measurable parameters that characterises it. The predictions of the model were tested by analysing two different cases: self sustained genetic oscillations from cycardian rhythms and in the transient oscillatory gene expression from cells extracted from the presomitic mesoderm of zebrafish embryos.

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DPG-Physik > DPG-Verhandlungen > 2018 > Berlin