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Berlin 2018 – scientific programme

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MM: Fachverband Metall- und Materialphysik

MM 65: Functional Materials (Actuators, filters, sensors, shape memory)

MM 65.6: Talk

Thursday, March 15, 2018, 18:45–19:00, H 0106

Functionalized gold electrodes for sensing DNA mutationsGanesh Sivaraman1, Frank C. Maier1, Rodrigo Amorim2, Ralph H. Scheicher3, and •Maria Fyta11Institute for Computational Physics, University of Stuttgart, Germany — 2Universidade Federal Fluminense, Departamento de Física, Volta Redonda/RJ, Brazil — 3Department of Physics and Astronomy, Materials Theory, Uppsala University, Sweden

Derivatives of small diamond-like nanostructures, the diamondoids, are used to functionalize fold electrodes. Within the gap of these functionalized electrodes, different DNA units are placed. These are native nucleotides, as well as modified nucleotides, such as mutations and epigenetic markers. Using quantum-mechanical calculations together with the non-equilibrium Green's functions formalism, we investigate the electronic transport properties across the functionalized electrodes for the cases of all nucleotides place in the electrode gap. Distinct electronic signals were found, which give rise to different coupling strengths across the electrode gap. These signals occur at distinct values of the gating voltage and can uniquely characterize the nucleotide in the metallic gap. Specifically, they can clearly distinguish between the native and the mutated nucleotides. Accordingly, diamondoid functionalized electrodes can be used as a sensing setup within nanopore materials.

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