Regensburg 2019 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 13: Active matter I (joint session BP/CPP/DY)
BP 13.3: Vortrag
Mittwoch, 3. April 2019, 10:00–10:15, H4
Active Matter Invasion into Capillaries — •Felix Kempf1, Romain Mueller2, Erwin Frey1, Juila Yeomans2, and Amin Doostmohammadi2 — 1Arnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, Department of Physics, Ludwig-Maximilians-Universität München - Theresienstr. 37, D-80333 München, Germany — 2The Rudolf Peierls Centre for Theoretical Physics - Clarendon Laboratory, Parks Road, Oxford, OX1 3PU, UK
Biological active materials such as bacterial biofilms and eukaryotic cells thrive in confined microspaces. Here, we numerically show that combining growth dynamics with their intrinsic activity active material can use confinement as a mechanical guidance to achieve distinct modes of collective invasion. We assess the dynamics of the growing interface and classify these collective modes of invasion based on the activity of the active substance. While at small and moderate activities the active material grows as a coherent unit, we find blobs of active materials collectively detaching from the cohort above an activity threshold in a process reminiscent of the intravasation in cancer cells. We further characterise the mechanical mechanisms of transition between different modes of invasion.