Regensburg 2019 – scientific programme

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BP: Fachverband Biologische Physik

BP 31: Cell adhesion and migration, multicellular systems II

BP 31.1: Invited Talk

Friday, April 5, 2019, 09:30–10:00, H10

Mechano-chemical self-organization determines search pattern in migratory cells — •Milos Galic — Institute of Medical Physics and Biophysics, University of Muenster, Germany

Efficient signal detection is fundamental for motile cells. To optimize their search strategy, cells seeking signal inputs employ non-Brownian motion pattern. Combining experimental and theoretical analysis, we identify a self-organizing system for super-diffusive two-state motion. We demonstrate that nanoscale plasma membrane deformations at the leading edge nucleate a mechano-chemical feedback loop that mediates polarization longevity and in consequence migration persistence. The resulting two-state motion, defined by continuous transitions between random and persistent phases, reduces oversampling to expand the search area. Collectively, the findings establish a mechanism for optimized search efficiency of vertebrate cells in the absence of polarized signal inputs.