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Regensburg 2019 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 6: Poster I

BP 6.80: Poster

Montag, 1. April 2019, 17:30–19:30, Poster B2

Gel formation of self-interacting DNA strands — •Giacomo Bartolucci — MPI PKS Dresden, Germany

Aqueous DNA solutions can exhibit a variety of condensed phases, depending on their nucleotide sequence and control parameters such as temperature and DNA concentration. It has been shown that DNA strands composed of self-complementary strand segments can form hydrogel phases. Inspired by these findings, we introduce a simple lattice model accounting for different configurations of DNA strands, namely single stranded DNA and a folded hairpin-like configuration. Our model is used to predict the phase diagrams of the solution as a function of temperature and total DNA concentration. We find that the region corresponding to gel formation is bounded by an upper and lower limiting temperature where gels dissolve. This behavior is due to the fact that at low temperature all DNA strands are folded in hairpins while at high temperature entropy spreads out open strands. Additionally, we discuss how this phase diagram is affected by the number of self-complementary strand segments. Our model serves as a starting point to understand the constituting principles underlying self-assembling bio materials based on DNA.

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