Regensburg 2019 – wissenschaftliches Programm

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 58: Nanostructures, Nanostructuring and Nanosized Soft Matter

CPP 58.11: Vortrag

Donnerstag, 4. April 2019, 18:00–18:15, H13

Structural Characteristics of Small and Stable Coenzyme Q10 Nanoparticles produced by Antisolvent Precipitation — •Isabel Schuldes, Dennis M. Noll, Tobias Zech, and Tobias Unruh — Institute for Crystallography and Structural Physics, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany

The production of organic nanoparticles (NPs) via antisolvent precipitation (AP) is a less-invasive and low-cost alternative to top-down methods like high-pressure homogenization. Thus, AP is receiving growing attention, e.g. for the preparation of nanodispersions of pharmaceutical ingredients. For instance, the antioxidant coenzyme Q10 (Q10) has several health protective effects and Q10 NPs showed improved bioavailability compared to free Q10.

Here we report the structural characterization of Q10 NPs produced by AP. The NPs are analyzed by photon correlation spectroscopy (PCS), cryogenic transmission electron microscopy (CryoTEM), small-angle X-ray and neutron scattering (SAXS; SANS, KWS-1 at MLZ). In particular, the combination of SAXS and SANS studies allows the investigation of the molecular structure of the NPs and the interface between the NPs and the dispersion medium. Our experiments revealed, that Q10 NPs prepared by AP are stable with and without added stabilizer, have a particular small size (down to ~ 20 nm in diameter), and exhibit a specific stabilizing layer, suggesting a self-stabilizing process of the Q10 molecules.