Regensburg 2019 – wissenschaftliches Programm

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MA: Fachverband Magnetismus

MA 28: Bio- and molecular magnetism including biomedical applications

MA 28.1: Vortrag

Mittwoch, 3. April 2019, 09:30–09:45, H52

Magnetite-gold nanoparticles: from physics to theranostics — •Maria V. Efremova^1,2, Yulia A. Nalench², Eirini Myrovali³, Anastasiia S. Garanina^1,2, Victor A. Naumenko², Maxim A. Abakumov^2,4, Marina Spasova⁵, Michael Farle⁵, Alexander G. Majouga^1,2,6, Natalia L. Klyachko^1,2, and Ulf Wiedwald^2,5 — ¹MSU, Moscow, Russia — ²NUST MISIS, Moscow, Russia — ³AUTH, Thessaloniki, Greece — ⁴RNRMU, Moscow, Russia — ⁵UDE, Duisburg, Germany — ⁶MUCTR, Moscow, Russia

In this work, we prepare pairwise connected Fe₃O₄−Au hybrid nanoparticles (NPs) with diameters of 6-44 nm Fe₃O₄ and 3-11 nm Au aiming for optimized theranostics response in magnetic particle hyperthermia (MPH) and magnetic resonance imaging (MRI).

With increasing NPs diameter from 6 to 25 nm in agarose mimicking tissues, the MPH reveal that the specific loss power increases from 12 to 327 W*gFe⁻¹, while for the MRI, we observe the growth of the r₂-relaxivity from 118 to 612 mM⁻¹s⁻¹. The 25 nm and 44 nm diameter NPs show the similar theranostic performance. These values are significantly enhanced in comparison to other Fe₃O₄−Au hybrids due to their octahedral shape and large M_s. As a practical application, MRI-controlled drug delivery and dual-mode MRI/fluorescent imaging are presented for the optimized NPs size of 25 nm.

The reported study was funded by the Russian Foundation for Basic Research 18-33-01232 (fluorescent labeling of NPs) and Increase Competitiveness Program of NUST MISIS K3-2017-022 (magnetic measurements).