Regensburg 2019 – wissenschaftliches Programm

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MM: Fachverband Metall- und Materialphysik

MM 9: Topical session (Symposium MM): Correlative and in-situ Microscopy in Materials Research

MM 9.7: Vortrag

Montag, 1. April 2019, 18:00–18:15, H44

Revealing the Influence of Surfactants on the Fast Growth Kinetics of Organic Nanoparticles by In Situ Small-Angle Scattering Studies — •Dennis M. Noll, Isabel Schuldes, Torben Schindler, Tilo Schmutzler, and Tobias Unruh — Institute for Crystallography and Structural Physics, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany

The combination of small-angle X-ray and neutron scattering (SAXS/SANS) with the stopped-flow technique allows for in situ studies of fast structure formation processes. The presented time-resolved experiments enable classical SANS in the regime of few milliseconds for the first time by performing and summing up hundreds of stroboscopic measurements for each sample system.

With in situ SAXS and SANS the fast growth of poorly-water soluble active pharmaceutical ingredient nanoparticles during the antisolvent precipitation process has been studied. To reveal the influence of surfactants on the growth kinetics and the ripening of the organic model system, precipitation with two structurally different and commonly used surfactants, as well as precipitation without any surfactant have been studied. The results of the in situ SANS measurements show an early beginning of ripening already after 250 ms for all sample systems and increased growth kinetics for nanoparticles solubilized by micelles.

Additionally, first in situ SAXS and SANS results of a new and simple model system for small and long-term stable organic nanoparticles with a similar growth behavior will be presented.