Regensburg 2019 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 1: X-ray Imaging
ST 1.3: Vortrag
Montag, 1. April 2019, 15:30–15:45, H48
Evaluation of X-ray Dark-Field Signal for Imaging Ex-situ Human Lung Specimens and Structure Size Determination — •Kirsten Taphorn1, Fabio De Marco1, Jana Andrejewski1, Konstantin Willer1, Christian Braun2, Alexander Fingerle3, Franz Pfeiffer1,3, and Julia Herzen1 — 1Chair of Biomedical Physics, Department of Physics and Munich School of BioEngineering, TUM, Garching, Germany — 2Institute of Forensic Medicine, Ludwig-Maximilians University, München, Germany — 3Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, TUM, Munich, Germany
Grating-based x-ray dark-field (XDF) imaging accesses information on small-angle scattering properties of the sample. However, the appearance of different pathologies in XDF lung imaging is not yet known. To elucidate this question, we report the design and implementation of a preclinical study on ex-situ human lung specimens with a Talbot-Lau interferometric setup that provides a field-of-view comparable to an x-ray chest radiography system. We constructed a device for lung ventilation as well as a thorax phantom and performed measurements of ex-situ human lung specimens. Furthermore, we investigated the spectral XDF signal of several phantom materials and found a correlation with mean chord length (MCL) obtained from micro CT, a medically approved size measure for alveolar structure. Structural lung diseases are known to effect changes in MCL. Thus, we show that a prediction of structural properties using spectral XDF imaging is possible, potentially enhancing the diagnostic power of XDF lung imaging.