Regensburg 2019 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 1: X-ray Imaging
ST 1.9: Vortrag
Montag, 1. April 2019, 17:15–17:30, H48
Bismuth-Oxo-Clusters as Novel X-Ray Stain for Soft-Tissue Samples — •Toni Bürkner1, Madleen Busse1, Mark Müller1, Melanie A. Kimm2, and Franz Pfeiffer1,2 — 1Department of Physics and Munich School of BioEngineering, Technical University of Munich, 85748 Garching, Germany. — 2Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany.
X-ray absorption-based micro-computed tomography enables 3D imaging with micrometer resolution[1]. This technique is commonly used in material science and is interesting for medical and biological sample screening as it is a non-destructive imaging method. The big drawback of soft-tissue samples is their missing contrast, which is mandatory to visualize internal structures on a microscopic scale, which will enable compatibility with conventional 2D histology [2,3]. Contrast agents (stains) and staining protocols are developed to overcome this problem and enhance the contrast. Within this work, we present a novel staining method based on bismuth-oxo-clusters, which was especially developed for soft-tissue X-ray imaging . Different clusters were synthesized and tested on various soft-tissue samples such as whole mouse organs, e.g. spleen and kidney.
[1] Stock, S. R. (2009). Micro-Computed Tomography - Methodology and Applications. CRC Press, Boca Raton, FL.
[2] M. Müller et al, PNAS 114 (2017) 12378-12383.
[3] M. Busse and M. Müller et al, PNAS 115 (2018) 2293-2298.