BPCPPDYSOE21 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 11: Poster A: Single Molecule, Multicellular, Bioimaging, Focus Sessions, etc.

BP 11.15: Poster

Montag, 22. März 2021, 16:30–19:00, BPp

In-situ GiSAXS investigations of sprayed drugs on Peptide Hydrogel based matrix — •Naireeta Biswas^1,2, Elisabeth Erbes^1,2, Krishnayan Basuroy¹, Jose Velaquez Garcia¹, Sreevidya Thekku Veedu¹, Matthias Schwartzkopf¹, Calvin Brett^1,4, Stephan Roth^1,3, and Simone Techert^1,2 — ¹Deutsches Elektronen-Synchrotron (DESY), Notkestraβe 85, 22607 Hamburg, Germany — ²University of Göttingen, Institute for X-ray Physics, Friedrich-Hund-Platz 1, 37077 Göttingen, Germany — ³Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, 100 44 Stockholm, Sweden. — ⁴Department of Mechanics, KT Royal Institute of Technology, 100 44 Stockholm, Sweden

A controlled and personalized treatment is key to successful medication. We have designed a novel hybrid material- a matrix made of a mixture of hydrophilic carboxymethylated nanocellulose (CMC) hydrogel and disordered hydrophobic peptide hydrogel (P). Our investigations into this material are the first steps towards a novel drug delivery/carrier strategy that allows a controlled dosage of anti-COVID drugs embedded in the system. This gives us the opportunity to vary the local uptake in a hydrophobic or hydrophilic compartment in the matrix. The structural intercalation and the time-resolved process were investigated with in-situ grazing-incidence small-angle X-ray scattering (GISAXS) experiments while spraying the drug on the matrix. In this work, we have focused on the structural analysis of the peptide hydrogel system with the drugs. The structural analysis of the CMC fibers will be presented in the poster of Elisabeth Erbes.