BPCPPDYSOE21 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 11: Poster A: Single Molecule, Multicellular, Bioimaging, Focus Sessions, etc.
BP 11.42: Poster
Montag, 22. März 2021, 16:30–19:00, BPp
X-ray studies of photo-induced structural changes in lipid membranes — •Svenja Hövelmann1,3, Karin Hansen1, Jonas Warias1, Jule Kuhn1, Rajendra Giri1, Andrea Sartori1, Philipp Jordt1, Chen Shen3, Franziska Reise4, Olaf Magnussen1, Thisbe Lindhorst4, and Bridget Murphy1,2 — 1Institut für Experimentelle und Angewandte Physik, University of Kiel, Germany — 2Ruprecht Heansel Laboratory, University of Kiel, Germany — 3Deutsches Elektronen Synchrotron, Hamburg, Germany — 4Otto Diels-Institut für Organische Chemie, University of Kiel, Germany
For potential health science applications such as drug delivery, one interesting approach is to alter structure and interfacial tension in phospholipid membranes by embedding photoswitchable molecules. Understanding the dynamics of such photo-induced modifications is also of fundamental interest. Therefore, we investigate a 1,2-dipalmitoyl-phosphatidylcholine (DPPC) Langmuir film with embedded photoswitchable azobenzene-glycolipid molecules as a model system. We use multiple measurement technics to characterise the structural changes, their evolution and time scales with absorption spectroscopy, Langmuir isotherms, X-ray reflectivity and grazing incident X-ray diffraction. The azobenzene-glycolipids switch reversibly between their trans- and cis-conformation by illumination with UV and blue light and induce a reversible structural change in the membrane they are embedded. These studies were performed on multiple mixed monolayers with varying azobenzene-glycolipids in head size to investigate the relevance of the head group. Differences in terms of their switching behaviour and membrane conformations will be discussed.