BPCPPDYSOE21 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 17: Multicellular Systems II
BP 17.4: Vortrag
Dienstag, 23. März 2021, 12:00–12:20, BPb
Migration of immune cells in an obstacle park — •Doriane Vesperini1, Zeinab Sadjadi2, Heiko Rieger2, and Franziska Lautenschläger1 — 1Experimental Physics, Saarland University, 66123 Saarbrücken, Germany — 2Theoretical Physics, Saarland University, 66123 Saarbrücken, Germany
Several crucial processes in biological systems can be described as a search problem such as: finding food resources or pathogens. The presence of obstacles like non-targeted cells or extracellular matrix in biological environments induces a perturbation of the initial cell trajectory. For example, the presence of bystander cells has been shown to increase the velocity and the persistence of natural killer cells [1]. Besides obstacles density, their spatial disposition may also influence the search efficiency. It has been demonstrated that the density and geometry of pillar lattices affect migration strategies of cells [2].
We investigate how search efficiency is influenced by spatial arrangement of obstacles. A microfluidic device is designed to track HL60 cells differentiated into neutrophils in confined 2D environments. Our device consists of pillar forests distributed in triangular or square arrangements. We calculate the escape time and diffusion properties of the searcher in different densities and height of pillars and investigate which key parameters influence the search efficiency.
[1] Zhou X., et al. Scientific Reports (2017)
[2] Gorelashvili M., et al. New Journal of Physics (2014)