BPCPPDYSOE21 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 17: Multicellular Systems II
BP 17.6: Vortrag
Dienstag, 23. März 2021, 12:40–13:00, BPb
Learning the dynamics of cell-cell interactions in confined cell migration — •David Brückner1, Nicolas Arlt2, Alexandra Fink1, Pierre Ronceray3, Joachim Rädler2, and Chase Broedersz1,4 — 1Arnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, Ludwig-Maximilians-Universität, München — 2Faculty of Physics and Center for NanoScience, Ludwig-Maximilians-Universität, München — 3Center for the Physics of Biological Function, Princeton University, Princeton, NJ 08544, USA — 4Department of Physics and Astronomy, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
Contact-mediated cell-cell interactions play a key role in shaping the stochastic trajectories of migrating cells. But how can we describe the stochastic dynamics of colliding cells in a unifying theoretical framework? To address this question, we monitor stochastic cell trajectories in a micropatterned cell collider in which pairs of cells perform repeated cellular collisions. Capitalizing on this large experimental data set of coupled cell trajectories, we infer an interacting stochastic equation of motion that accurately predicts the observed interaction behaviors. Our approach reveals that interacting non-cancerous MCF10A cells can be described by repulsion and friction interactions. In contrast, cancerous MDA-MB-231 cells exhibit novel and surprising attraction and anti-friction interactions, promoting the predominant relative sliding behavior observed for these cells. Based on the inferred interactions, we show how our framework may generalize to provide a unifying theoretical description of diverse cellular interaction behaviors.