BPCPPDYSOE21 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 4: Cell Mechanics II
BP 4.5: Vortrag
Montag, 22. März 2021, 12:20–12:40, BPa
Thermodynamics of caveolae formation and mechanosensing — •Niladri Sarkar1,2 and Pierre Sens2 — 1Instituut-Lorentz, Universiteit Leiden, P.O. Box 9506, 2300 RA Leiden, Netherlands. — 2Laboratoire Physico Chimie Curie, Institut Curie, CNRS, 75005 Paris, France.
Caveolae are invaginations in cell membranes formed by proteins in the caveolin and cavin family self-aggregating in the membrane to form buds. These buds also have some proteins from the EHD family aggregating at their necks. We have developed a two component equilibrium model for the thermodynamics of these bud formation process using energy considerations, where the caveolin proteins are considered as one component and the neck proteins are taken to be another. We have found that depending on the surface tension of the membrane, the line tension associated with the different proteins and the concentration of the different proteins, invaginations of different shapes and sizes can be obtained, and there can be a transition from a fully budded state to a non-budded state via a partial budded state. Also neck proteins are found to provide extra mechano-protection against disassembly due to surface tension.