SKM 2021 – wissenschaftliches Programm
CPP 6.1: Poster
Dienstag, 28. September 2021, 17:30–19:30, P
Self-assembled micelles in aqueous diblock copolymer solution — •Yanan Li1, Chia-Hsin Ko1, Varvara Chrysostomou2, Dmitry Molodenskiy3, Stergios Pispas2, and Christine M. Papadakis1 — 1Physics Department, Technical University of Munich, Garching, Germany — 2Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, Athens, Greece — 3EMBL at DESY, Hamburg, Germany
Micelles with stimuli-responsive behavior have attracted great interest as nanocarriers, especially for drug delivery. Here, we investigate the diblock copolymer poly(2-(dimethylamino) ethyl methacrylate)-b-poly(lauryl methacrylate) (PDMAEMA-b-PLMA), having both pH and thermoresponsive properties in aqueous solution . The self-assembled micelles can be applied in gene transfer and drug delivery applications. We investigate both the pH-dependent micellar structures depending on concentration and the designable micellar shapes from two preparation methods by dynamic light scattering and synchrotron small-angle x-ray scattering. Depending on the preparation method, cylindrical or ellipsoidal micelles are formed. In addition, as the solution is brought from the basic to the acidic state, the micellar size increases, which we attribute to the expansion of the charged PDMAEMA blocks.
 V. Chrysostomou, S. Pispas, J. Polym. Sci. A: Polym. Chem. 2018, 56, 598.