SKM 2021 – wissenschaftliches Programm

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DY: Fachverband Dynamik und Statistische Physik

DY 13: Focus session: Nonlinear Dynamics of the Heart II (organized by Markus Bär, Stefan Luther and Ulrich Parlitz)

DY 13.4: Hauptvortrag

Donnerstag, 30. September 2021, 14:45–15:15, H2

Cardiac repolarization dynamics and arrhythmias in healthy and diseased hearts — •Esther Pueyo — University of Zaragoza, Zaragoza, Spain

The electrical activity of the heart is the result of a set of complex nonlinear biophysical and biochemical processes occurring at different scales within the cardiac tissue. The variability arising from these processes translates into variability at the cell, tissue, organ and whole-body levels. The importance of investigating variability in cardiac electrical activity, in general, and in cardiac repolarization (i.e. the return of cells to their resting state after electrical activation), in particular, has been well documented, having shown value for diagnosis, monitoring and treatment of cardiac diseases.

In this talk, I will present studies combining computational, experimental and clinical methods to investigate temporal and spatial variability in cardiac repolarization. I will show the role of stochasticity in contributing to this variability in health and diseased hearts. The link between enhanced repolarization variability and pro-arrhythmia will be described, with emphasis on the role of the autonomic nervous system as a modulator of this link.