SKM 2021 – wissenschaftliches Programm

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HL: Fachverband Halbleiterphysik

HL 13: Poster Session III

HL 13.17: Poster

Dienstag, 28. September 2021, 13:30–16:30, P

Wave Digital Emulation of Hydra's Neuronal Activity — •Sebastian Jenderny1, Karlheinz Ochs1, Christoph Giez2, Alexander Klimovich2, and Thomas Bosch21Ruhr University Bochum, Chair of Digital Communication Systems, Bochum, Germany — 2Christian-Albrechts University Kiel, Zoological Institute, Kiel, Germany

Modeling real neuronal networks by electrical circuits is especially interesting as it can reveal novel design principles. A promising model organism for this purpose is Hydra, a freshwater polyp with rich behavioral patterns despite its neuronal network only consisting of roughly 3000 neurons. Modeling Hydra's nerve net by an electrical circuit is, however, challenging as only calcium imaging measurements instead of electrophysiology are available. The neuronal activity associated to these calcium imaging measurements are difficult to mimic by electrical circuits as they are based on fluorescence traces instead of voltage and current measurements. In this work, we present a circuit-based approach to mimic these fluorescence traces utilizing the fact that the latter can be used to determine the intracellular calcium concentration. For this purpose, we make use of the Morris-Lecar model already accounting for calcium currents and hence allowing to calculate a calcium concentration comparable to the one inferred from the fluorescence traces. A wave digital emulation of our circuit approach shows the successful mimicking of exemplary neuronal activity of Hydra.

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