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BP: Fachverband Biologische Physik

BP 12: Poster 2

BP 12.25: Poster

Tuesday, September 6, 2022, 17:30–19:30, P4

Mechanical Characterization of Pharmaceutical Nanoparticles — •Henrik Siboni^{1, 2}, Leonhard Grill¹, and Andreas Zimmer² — ¹Single Molecule Chemistry, Institute of Chemistry, University of Graz — ²Pharmaceutical Technology & Biopharmacy, Institute of Pharmaceutical Sciences, University of Graz

Nanoscale Drug Delivery Systems are becoming an essential part of modern medicine, but lack of understanding of the underlying physical mechanisms hinders its progress. Focusing on self-assembled nanoparticles called proticles, we employ Atomic Force Microscopy to gain new insights. We find that we are able to characterize particle shape and its dependence on formulation. We further show that proticles can be imaged on biological cells and that the mechanical changes in cells can be measured using nanoindentation experiments. Our methods can be used in the future to accelerate early-stage development of pharmaceutical nanoparticles.