Regensburg 2022 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 18: Biomaterials (joint session BP/CPP)

BP 18.8: Vortrag

Mittwoch, 7. September 2022, 17:15–17:30, H15

Adsorption of laminin and cellular response of neurons and glial cells on ion implanted titania nanotube scaffolds — •Jan Frenzel1,2,3, Astrid Kupferer1,2, Mareike Zink3, and Stefan G. Mayr1,21Leibniz Institute of Surface Engineering (IOM), Permoserstraße 15, 04318 Leipzig, Germany — 2Division of Surface Physics, Department of Physics and Earth Sciences, Linnéstraße 5, 04103 Leipzig, Germany — 3Research Group Biotechnology and Biomedicine, Department of Physics and Earth Sciences, Linnéstraße 5, 04103 Leipzig, Germany

Brain-machine interfaces are used in a wide spectrum of neuroscience, as for time-resolved sensing of neural activities and for tackling neurodegenerative diseases. Currently established cultivation platforms, including cellulose filters, often result in loss of long-term adhesion, rejection reaction and glial scarring or do not allow for electrical contact due to their insulating properties. As we demonstrate, ion implanted titania nanotube scaffolds (TNS) are a promising candidate to overcome these issues, since they combine a high biocompatibility with a sufficient large electrical conductivity. In our experiments, we explain how ion implantation induced changes of surface characteristics affect the adsorption of laminin and the viability and adhesion of neurons and glial cells. We link the hindered laminin adsorption due to implantation to the shrinkage of tube diameter and rise of zeta potential. The stable and high neuron viability on all TNS but suppressed glial cell formation of implanted TNS gives rise for a potential interface material. Funding by SMWK (100331694) is gratefully acknowledged.

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