DPG Phi
Verhandlungen
Verhandlungen
DPG

Regensburg 2022 – scientific programme

Parts | Days | Selection | Search | Updates | Downloads | Help

BP: Fachverband Biologische Physik

BP 22: Migration and Multicellular Systems

BP 22.5: Talk

Thursday, September 8, 2022, 11:00–11:15, H15

Exploiting Onsager regression in passive measurements to reveal active mechanics of living systemsTill Münker, Gabriel Knotz, Matthias Krüger, and •Timo Betz — Faculty of Physics, Georg-August-University Göttingen

Understanding life is arguably among the most complex scientific problems faced in modern research. From a physics perspective, living systems are complex dynamic entities that operate far from thermodynamic equilibrium. This active, non-equilibrium behaviour, with its constant hunger for energy, allows life to overcome the dispersing forces of entropy, and hence drives cellular organisation and dynamics at the micrometer scale. Unfortunately, most analysis methods provided by the powerful toolbox of statistical mechanics cannot be used in such non-equilibrium situations, forcing researchers to use sophisticated and often invasive approaches to study the mechanistic processes inside living organisms. Inspired by Onsager's regression hypothesis, we introduce here a Mean Back Relaxation (MBR) observable, which detects active motion in purely passive measurements of particle fluctuations. The MBR, which is based on three point probabilities, is theoretically and experimentally shown to exhibit markers of non-equilibrium, i.e., of detailed balance breaking dynamics. We furthermore observe an astonishing relation between the MBR and the effective non-equilibrium energy in living cellular systems. This is used to successfully predict the viscoelastic response function and the complex shear modulus from a purely passive approach, hence opening the door for rapid and simple passive mechanics measurements even in active systems.

100% | Mobile Layout | Deutsche Version | Contact/Imprint/Privacy
DPG-Physik > DPG-Verhandlungen > 2022 > Regensburg