SKM 2023 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 28: Poster Session II

BP 28.27: Poster

Donnerstag, 30. März 2023, 18:00–20:00, P2/EG

Burst Mode of Ultrasonic Resonant Oscillations for Stimulation and Destruction of Tumor Cells — •Birte Sehlmeyer1, Rebecca Kampmann1, Claus Scheidemann2, Tobias Hemsel2, and Mathias Getzlaff11Applied Physics, Düsseldorf University — 2Dynamics and Mechatronics, Paderborn University

Different types of cancer, such as prostate carcinomas, are nowadays already treated with the ultrasound-based therapy HIFU (high intensity focused ultrasound). The healthy cells, which are located in the irradiation field, cannot be spared in this process. The elasticity differences between cancer cells and healthy cells strongly influence their stimulation frequency. LIPUS (low intensity pulsed ultrasound) is used to selectively stimulate and destroy cancer cells close to their own natural frequency, while sparing locally adjacent healthy cells.

Here we report new findings on the maximum oscillation amplitude of an ultrasound unit in burst mode. In burst mode, there is only a signal output during the active times.The ultrasonic actuators were electrically excited using a flexible ultrasonic generator developed by ATHENA Technologie Beratung GmbH, Paderborn. The excitation of the ultrasonic unit was varied by setting the targets current amplitude and the active time. Regarding the characteristic stimulation frequency of tumor cells, the frequency spectrum and frequency filters are discussed. In addition to the longitudinal deflection amplitude, an oscillation in the transverse direction was observed. Finally, the transverse oscillation behavior is investigated in relation to half-wave synthesis.

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