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DY: Fachverband Dynamik und Statistische Physik
DY 13: Active Matter III (joint session BP/CPP/DY)
DY 13.9: Talk
Tuesday, March 28, 2023, 11:45–12:00, TOE 317
Hydrodynamic description and transport coefficients in a model of active cellular aggregates — •Subhadip Chakraborti1,2 and Vasily Zaburdaev1,2 — 1Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany — 2Max-Planck-Zentrum für Physik und Medizin, Erlangen, Germany
Complex multicellular aggregates consisting of a large number of interacting cells are ubiquitous in biology, ranging from bacterial biofilms to organoids, cell spheroids, and tumors. We consider colonies of N. gonorrhoeae bacteria as a prototypical example of cells that use retractile cell appendages to actively interact with a substrate and with each other. We construct a microscopic model on a 1D lattice taking into account the non-equilibrium bacterial motility driven by two crucial forces – cell-substrate and cell-cell interactions. We observe a phase transition from a homogeneous state to a clusterized state upon tuning the density and activity parameters. Using macroscopic fluctuation theory (MFT), we analytically derive hydrodynamics for the model system and calculate two density-dependent transport coefficients – the bulk-diffusion coefficient and the conductivity. The behavior of these transport coefficients successfully explains the non-equilibrium phase transition. We support our analytical findings with the results obtained numerically. Our theory provides a general framework for studying the non-equilibrium collective behavior of other dense cellular aggregates also, in the context of dynamics and their transport properties.