SKM 2023 – wissenschaftliches Programm
DY 3.4: Vortrag
Montag, 27. März 2023, 10:30–10:45, TOE 317
Geometry-induced patterns in collective cell migration — •David Brückner — Institute of Science and Technology, Am Campus 1, 3400 Klosterneuburg, Austria
The coordinated migration of cell collectives is increasingly well understood at the level of large two-dimensional confluent monolayers. However, many physiological migration processes rely on small polarized cell clusters and their responses to external confining geometries, such as 2D channels and 3D curved environments. How active motion and cell-cell interactions interplay with such external boundaries remains poorly understood. I will discuss how external geometries can induce patterns in collective cell migration, using two examples. First, we show that the migration efficiency of 2D confined cell clusters is determined by the contact geometry of cell-cell contacts that are either parallel or perpendicular to the direction of migration. Our minimal active matter model reveals how cell-cell interactions determine a geometry-dependent supracellular stress field that controls this response to external boundaries. Secondly, we show how the interplay of curvature and active flocking dynamics of 3D cell spheroids induces a collective mode of cell migration manifesting as a propagating velocity wave. Together, these approaches provide a conceptual framework to understand how cell-cell interactions interplay with 2D and 3D geometries to determine the emergent dynamics of collective cell migration.