SKM 2023 – wissenschaftliches Programm
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DY: Fachverband Dynamik und Statistische Physik
DY 52: Statistical Physics of Biological Systems II (joint session BP/DY)
DY 52.7: Vortrag
Freitag, 31. März 2023, 11:15–11:30, BAR Schö
Clonal dynamics at tissue interfaces — •Ruslan Mukhamadiarov1,2, Matteo Ciarchi1,2, Fabrizio Olmeda1,2, and Steffen Rulands1,2 — 1Ludwig Maximilian University of Munich, München, Germany — 2Max Planck Institute for the Physics of Complex Systems, Dresden, Germany
Tissue morphogenesis relies on the spatial separation of different cell types. Understanding how cells regulate the positions of such interfaces is key to understanding the processes that occur during dysregulation, such as in cancer. Genetic tracing has become an important experimental tool in studying the regulation of cell behaviour. However, its use in both homeostatic and growing tissues is limited by the emergence of universal size distributions. Here, we show that the mechanisms of tissues interface regulation is reflected in cell-fate specific size distributions of genetically labelled cells, termed clones. Specifically, we show how interface fluctuations affect the size distributions of labelled clones and derive theoretical predictions for a range of biologically relevant scenarios that can be tested experimentally. We test our theoretical framework by stochastic simulations and analysis of live imaging experiments. By relating interface fluctuations to clone size distributions our work paves the way for using genetic tracing experiments to understand the mechanisms underlying tissue compartmentalization.