Dresden 2026 – scientific programme
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BP: Fachverband Biologische Physik
BP 14: Poster Session II
BP 14.27: Poster
Tuesday, March 10, 2026, 18:00–21:00, P2
Elucidating the dynamics of DNA-based Transmembrane Receptors through Molecular Dynamics Simulations — •Cyrille Ngueldjou Tahabo1, Doruk Baykal2, Lorena Baranda Pellejero2, Andreas Walther2, and Lukas Stelzl3,4 — 1Institute of Physics,University of Johannes Gutenberg,Mainz,Germany — 2Department of Chemistry,University of Johannes Gutenberg,Mainz,Germany — 3Institute of Molecular Physiology, University of Johannes Gutenberg, Mainz, Germany — 4Institut of Molecular Biology, Mainz (IMB), Germany
Building an artificial cell is an essential step to creating artificial life-like systems and a critical step in this endeavour is to design molecular systems which enable the communication of an artificial cell with its environment. Such artificial life-like systems hold great promise for biomedical engineering. By mimicking biological mechanisms to enable the transmission of information from the exterior of artificial cells across membranes to their interior, we will contribute to creating new artificial life-like systems and gain insights to essential biological information processing mechanisms and advance simulation method development, using an atomistic molecular dynamics and Coarse Grained simulations approaches, who can be synthesized to function as receptors in artificial life-like systems. we study DNA attached to an anchor insert in lipid membranes. In the simulations we investigate how Anchor interacts with the membranes and how DNA-Anchor changes local membrane structure.
Keywords: Transmembrane Receptors; Molecular Dynamics; atomistic molecular dynamics; Coarse Grained simulation; DNA nanosensors