Dresden 2026 – scientific programme
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BP: Fachverband Biologische Physik
BP 14: Poster Session II
BP 14.39: Poster
Tuesday, March 10, 2026, 18:00–21:00, P2
Lens-free lab-on-chip fluorescence microscopy using angle-stable polariton filters — •Anja Lindenau1, Andreas Mischok1, and Malte Gather1,2 — 1Humboldt Centre for Nano- and Biophotonics, Department of Chemistry, University of Cologne, Germany — 2School of Physics and Astronomy, University of St Andrews, Scotland
Fluorescence microscopy is an essential tool in biomedical research but typically relies on complex optical setups with high-numerical-aperture objectives and specialised colour filters, which results in a large footprint and high acquisition costs. Here, we present a modified commercial CMOS image sensor for lens-free fluorescence microscopy. Lens-free imaging enables compact, low-cost systems with a large field-of-view (> 20 mm) and pixel-limited resolution (1.4 micrometer). To overcome the limitations of conventional colour filters, in particular their strong angular dispersion, we integrate a polariton-based filter directly on the sensor. This novel filter design exploits ultra-strong light-matter coupling between photons and material excitons, maintaining a stable long-pass cut-off below 540 nm over a broad range of incidence angles and thereby drastically improving the signal-to-noise ratio. Initial results highlight the potential for high-resolution on-chip lens-free fluorescence microscopy with significantly enhanced image quality.
Keywords: lensless fluorescence imaging; lab-on-chip