Dresden 2026 – scientific programme
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BP: Fachverband Biologische Physik
BP 14: Poster Session II
BP 14.50: Poster
Tuesday, March 10, 2026, 18:00–21:00, P2
A Mathematical Model of Microlesion-Driven Calcium Signalling in Fibroblast Networks — •Kara Nachtnebel1,2,3,5, Eric Greto1,2,3, Anna Möller1,2,3,6, Christian Maueröder1,2,3, David B. Blumenthal6, Vasily Zaburdaev4,5, and Stefan Uderhardt1,2,3 — 1Department of Medicine 3 - Rheumatology and Immunology, FAU und Universitätsklinikum Erlangen — 2Deutsches Zentrum für Immuntherapie, FAU — 3Exploratory Research Unit, Optical Imaging Centre Erlangen, FAU — 4Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) — 5Max-Planck-Zentrum für Physik und Medizin, Erlangen — 6Department of Artificial Intelligence in Biomedical Engineering, FAU, Erlangen, Germany
Resident tissue macrophages (RTMs) maintain tissue homeostasis by continuously sensing and integrating local environmental signals. The interstitial fibroblast network, an omnipresent, self-interconnected system capable of generating intracellular calcium signals and transmitting them to neighbouring cells, provides signals that RTMs can detect and respond to. For example, in response to calcium elevations associated with tissue lesions, macrophages initiate rapid cloaking behaviour. Disruption of fibroblast networks can amplify unwanted immune activation and may contribute to the development of autoimmune diseases. We present a mathematical model of microlesion-induced calcium signalling in gap-junction-coupled fibroblast networks. It shows how microlesions drive signal propagation via intra- and extracellular pathways and quantifies the factors that shape this process.
Keywords: fibroblast networks; calcium signaling; tissue microlesions; mathematical modeling; Macrophages