Dresden 2026 – scientific programme
Parts | Days | Selection | Search | Updates | Downloads | Help
BP: Fachverband Biologische Physik
BP 14: Poster Session II
BP 14.9: Poster
Tuesday, March 10, 2026, 18:00–21:00, P2
Mathematical modeling of larvae motility in complex environments — •Sreya Chatterjee1, Jhanvi H. Patel2, David Voehringer2, and Vasily Zaburdaev1 — 1MPZPM, Erlangen,Germany — 2Department of Infection Biology,University Hospital Erlangen,Friedrich-Alexander University,Erlangen.Germany
N. brasiliensis is one of the most widely-studied helminth parasites due to the relatively simple life cycle for parasite production and its ability to be used in animal models, especially rodents. The larvae mature into adult worms in the lumen of the small intestine, which is composed of mucus produced by goblet cells. Studying their interactions with the surrounding host tissue will help us understand how helminths trigger and modulate immune responses. The mucus layer of the extracellular matrix is viscoelastic which influence their motility. We model these adult worms as active agents exhibiting persistent motion within this viscoelastic environment. To capture their dynamics, we formulate the problem using the well-established framework of Active Brownian Particles (ABPs). As a first step, we study the behavior of a simple system of two ABPs connected by a spring through analytical approaches as well as numerical simulations. Next we will extend this model to simulate N-particles connected by springs to capture a more realistic model of the movement of the worm in viscoelastic environment.
Keywords: helminth; viscoelastic; active Brownian motion